Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Cell Culture Media, Supplements, and Reagents
  4. Cell Culture Reagents, Antibiotics and Supplements
  5. Antibiotics
  6. J62473MCPM

Rapamycin, 98+%, Thermo Scientific Chemicals PROMO

Catalog No. J62473MCPM
Change view
Click to view available options
:
100 mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No.
J62473MCPM 100 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. J62473MCPM Supplier Thermo Scientific Chemicals Supplier No. J62473MCPR

Description

Rapamycin, CAS # 53123-88-9, is a macrolide compound showing suppressor activity against the immune system and also exhibits inhibitory activity in tumor growth.

General Description

  • Rapamycin is a natural macrolide compound showing antiproliferative activities in mammalian cells
  • Rapamycin is a specific inhibitor of rapamycin kinase. It forms a complex with FKBP12 that consequently binds and inhibits rapamycin's molecular target (rapamycin kinase)

Application

  • Rapamycin inhibits tumor growth by preventing tumor cell proliferation and suppressing tumor angiogenesis
  • This compound also blocks cytokine-mediated signal transduction pathways
  • Rapamycin also promotes the suppression of the immune system
  • It was initially defined as an antifungal metabolite produced by Streptomyces hygroscopicus
  • In vitro studies demonstrated that this compound is an important mediator of PI3 kinase signaling
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 53123-88-9
Molecular Formula C51H79NO13
Molecular Weight (g/mol) 914.187 g/mol
MDL Number MFCD00867594
InChI Key QFJCIRLUMZQUOT-HPLJOQBZSA-N
Synonym Sirolimus; AY-22989
PubChem CID 5284616
ChEBI CHEBI:9168
SMILES CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC

Specifications

Type Rapamycin
Physical Form Powder
Color White
Quantity 100 mg
Merck Index 14,8114
Solubility Information Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in Alcohol,dimethyl sulfoxide and dimethyl formamide; Insoluble in Water.
Formula Weight 914.17 g/mol
Percent Purity ≥99%
Chemical Name or Material Rapamycin

Safety and Handling

RTECSNumber VE6250000
TSCA No
Recommended Storage Store at -20°C

RUO – Research Use Only

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.