Rapamycin, 98+%, Thermo Scientific Chemicals PROMO

Description

Rapamycin, CAS # 53123-88-9, is a macrolide compound showing suppressor activity against the immune system and also exhibits inhibitory activity in tumor growth.

General Description

• Rapamycin is a natural macrolide compound showing antiproliferative activities in mammalian cells
• Rapamycin is a specific inhibitor of rapamycin kinase. It forms a complex with FKBP12 that consequently binds and inhibits rapamycin's molecular target (rapamycin kinase)

Application

• Rapamycin inhibits tumor growth by preventing tumor cell proliferation and suppressing tumor angiogenesis
• This compound also blocks cytokine-mediated signal transduction pathways
• Rapamycin also promotes the suppression of the immune system
• It was initially defined as an antifungal metabolite produced by Streptomyces hygroscopicus
• In vitro studies demonstrated that this compound is an important mediator of PI3 kinase signaling

Specifications

Chemical Identifiers

• CAS: 53123-88-9
• Molecular Formula: C51H79NO13
• Molecular Weight (g/mol): 914.187 g/mol
• MDL Number: MFCD00867594
• InChI Key: QFJCIRLUMZQUOT-HPLJOQBZSA-N
• Synonym: Sirolimus; AY-22989
• PubChem CID: 5284616
• ChEBI: CHEBI:9168
• SMILES: CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC

• Type: Rapamycin
• Physical Form: Powder
• Color: White
• Quantity: 100 mg
• Merck Index: 14,8114
• Solubility Information: Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in Alcohol,dimethyl sulfoxide and dimethyl formamide; Insoluble in Water.
• Formula Weight: 914.17 g/mol
• Percent Purity: ≥99%
• Chemical Name or Material: Rapamycin

Safety and Handling

RTECSNumber	VE6250000
TSCA	No
Recommended Storage	Store at -20°C

RUO – Research Use Only