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Invitrogen™ RARB Polyclonal Antibody
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Catalog No. PA1811
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100 μL
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PA1811 100 μL
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Catalog No. PA1811 Supplier Invitrogen™ Supplier No. PA1811
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Description

Rabbit Polyclonal Antibody

PA1-811 detects retinoic acid receptor (RAR) beta from human and mouse tissues. This antibody shows slight cross-reactivity to RAR alpha but does not detect RAR gamma. PA1-811 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~52 kDa protein representing RAR beta from SH-SY5Y (human neuroblastoma) cell extract. The PA1-811 immunogen is a synthetic peptide corresponding to residues P(429) S V S P S S V E N S G V S Q S P L L Q(448) of mouse RAR beta. This immunizing peptide (Cat. # PEP-005) is available for use in neutralization and control experiments.

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RARB
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Whole serum, PBS with 0.05% sodium azide
Gene RARB
Gene Accession No. P10826, P22605
Gene Alias A830025K23; HAP; HBV-activated protein; hepatitis B virus activated protein; MCOPS12; NR1B2; nuclear receptor subfamily 1 group B member 2; RAR beta; Rarb; RAR-b; RAR-beta; RARbeta1; RAR-Beta2; RAR-Beta4; RAR-epsilon; retinoic acid; retinoic acid receptor; retinoic acid receptor beta; retinoic acid receptor, beta; retinoic acid receptor, beta polypeptide; RRB2
Gene Symbols RARB
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues P(429) S V S P S S V E N S G V S Q S P L L Q(448) of mouse RAR beta.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 218772, 5915
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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