Invitrogen™ Ras (G12D Mutant) Recombinant Rabbit Monoclonal Antibody (HL10)

Catalog No.	Quantity
PIMA536256	100 μL

Catalog No. PIMA536256 Supplier Invitrogen™ Supplier No. MA536256

Description

Rabbit Recombinant Monoclonal Antibody

Ras (G12D Mutant) Recombinant Monoclonal Antibody for IHC (P), Western Blot

Ras is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. The process of shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in Ras gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.

Specifications

• Antigen: Ras (G12D Mutant)
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Recombinant Monoclonal
• Clone: HL10
• Concentration: 1.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative
• Gene: NRAS
• Gene Accession No.: P01111, P08556
• Gene Alias: ALPS4; AV095280; CMNS; GTPase NRas; HRAS1; NCMS; neuroblastoma ras oncogene; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; NRAS; N-ras; N-ras protein part 4; NRAS1; NS6; transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog
• Gene Symbols: NRAS
• Host Species: Rabbit
• Immunogen: Carrier-protein conjugated synthetic peptide surrounding mutant G12D of human K-Ras. The exact sequence is proprietary.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18176, 4893
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG