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Invitrogen™ RASGRP1 Polyclonal Antibody
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Catalog No. PIPA583459
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PIPA583459 100 μL
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Catalog No. PIPA583459 Supplier Invitrogen™ Supplier No. PA583459
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RKTAQDTLYV LPSPTSPCPS PVLVRKRAFV KWENKDSLIK SKEELRHLRL PTYQELEQEI NTLKADNDAL KIQLKYAQKK IESLQLEKSN HVLAQMEQGD Highest antigen sequence indentity to the following orthologs: Rat - 82%, Mouse - 85%.

Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RASGRP1
Applications Immunocytochemistry, Immunofluorescence
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene RASGRP1
Gene Accession No. O95267
Gene Alias Calcium and DAG-regulated guanine nucleotide exchange factor II; calcium- and diacylglycerol-regulated guanine nucleotide exchange factor II; CALDAG-GEFI; CALDAG-GEFII; guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A; hRasGRP1; ras activator RasGRP; RAS guanyl nucleotide-releasing protein 1; RAS guanyl releasing protein 1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); Ras guanyl-releasing protein; RAS guanyl-releasing protein 1; RASGRP; RASGRP1; V
Gene Symbols RASGRP1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human RASGRP1. Recombinant protein control fragment (Product #RP-106113).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10125
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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