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AdipoGen RasGRP2 pSer587 pAb IG1209
Supplier: AdipoGen AG25T0119C020
Polyclonal Antibody. Recognizes human and mouse RasGRP2 phosphorylated at pSer587 human isoform 1, pSer586 mouse or pSer649 human isoform 2. Source Rabbit. Applications WB. Liquid. In PBS containing 2mg/ml BSA and 0.05% sodium azide. RasGRP2 functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating small GTPases, including Rap1/RAS3, through the exchange of bound GDP for GTP. It may also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. The protein is expressed in platelets, neutrophils and T lymphocytes. RasGRP2 functions in aggregation of platelets and adhesion of T lymphocytes and neutrophils probably through inside-out integrin activation. S587 was identified as the major PKA phosphorylation. Phosphorylation of S587 correlated with the inhibitory effect of PKA on Rap1b activation in platelets.
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