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CD51 Rat anti-Mouse, Brilliant Violet 421, Clone: RMV-7, BD Optibuild™

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 740062

Catalog No. BDB740062


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Description

Description

The RMV-7 monoclonal antibody specifically binds to CD51, the 140 kDa integrin α V chain. Heterodimers of CD51 with several integrin β chains function as receptors for extracellular matrix proteins. CD51/CD61 ( α V β 3 integrin, vitronectin receptor) mediates adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, von Willebrand factor, and CD31 (PECAM-1). CD51 is expressed on activated T lymphocytes, polymorphonuclear granulocytes, blastocysts, and osteoclasts. CD51 is reportedly not detectable on mouse platelets using either H9.2B8 or RMV-7 antibody clones. CD51 also forms heterodimers with CD29 (integrin β 1), integrins β 5, β

The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50-nm filter). BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates.

Specifications

Specifications

CD51
RMV-7
Brilliant Violet 421
Aqueous buffered solution containing ≤0.09% sodium azide.
Rat
IgG1, κ
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
0.2mg/mL
Itgav; Integrin alpha-V; Integrin αV ; VNRA; Vitronectin receptor alpha
Affinity Purified
Mouse (BALB/c) IL-2-activated killer (LAK) Cells
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
RUO
Primary
Murine
Documents
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