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Siglec-F Rat anti-Mouse, Brilliant Violet 650, Clone: E50-2440, BD Optibuild™

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BDB740557 50 μg
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Catalog No. BDB740557 Supplier BD Biosciences Supplier No. 740557
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Description

Rat Monoclonal Antibody

The E50-2440 monoclonal antibody specifically recognizes Siglec-F. Siglecs are the s ialic acid-binding immunoglobulin superfamily lectins defined in the human, each of which has a distinctive expression pattern in the hematopoietic system and at least some of which are known to mediate cell-cell interactions. Orthologous proteins of human Siglec-1 (Sialoadhesin or CD169), Siglec-2 (CD22), and Siglec-4 (myelin-associated glycoprotein) have been characterized in the mouse. Human Siglec-3 (CD33) and Siglecs-5 through -10 are encoded by a cluster of closely related genes, and each has two cytoplasmic ITIM (Immunoreceptor Tyrosine-based Inhibitory Motifs). Similarly, mouse Siglec-F is encoded by a gene in a syntenic cluster in the mouse, and the protein has sialic acid-binding activity and an intracytoplasmic ITIM. Its expression pattern differs from those of the human Siglec-3-related proteins in that it is found on immature cells of the myelomonocytic lineage, with reduced expression on mature neutrophils and monocytes, and not on lymphoid cells. It has been proposed that mAb E50-2440 may be used for identification of immature myelomonocytic cells in the mouse.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Siglec-F
Applications Flow Cytometry
Classification Monoclonal
Clone E50-2440
Concentration 0.2mg/mL
Conjugate Brilliant Violet 650
Description Siglecf; Siglec5; sialic acid binding Ig-like lectin 5; SIGL5; Siglec-5
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse Siglec-F and human IgG Fc recombinant fusion protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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