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Spi-B Rat anti-Mouse, PE, Clone: U14-267, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 565834

Catalog No. BDB565834


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Description

Description

The U14-267 monoclonal antibody specifically recognizes mouse Spi-B, that is encoded by Spib (Spi-B transcription factor (Spi-1/PU.1 related)). Spi-B belongs to the Ets family of transcription factors. It is expressed predominantly in B cells, T-cell progenitors, and plasmacytoid dendritic cells. Spi-B plays crucial roles in the development of T cells and plasmacytoid dendritic cells, and in the terminal differentiation of B cells. Although Spi-B deficient mice have normal numbers of B cells, they exhibit defects in germinal center formation and maintenance. In contrast, overexpression of Spi-B blocks plasma cell differentiation due to its capacity to repress Blimp-1 and Xbp-1 expression.

Specifications

Specifications

Spi-B
U14-267
PE
Aqueous buffered solution containing ≤0.09% sodium azide.
Rat
IgG2a, κ
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry, Immunocytochemistry
0.2mg/mL
SPI-B; Spib; Spi-1/PU.1 related; Ets transcription factor Spi-B
Affinity Purified
Mouse Spi-B Recombinant Protein
Affinity Chromatography
RUO
Primary
Murine
Documents
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