Spi-B Rat anti-Mouse, PE, Clone: U14-267, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 565834
The U14-267 monoclonal antibody specifically recognizes mouse Spi-B, that is encoded by Spib (Spi-B transcription factor (Spi-1/PU.1 related)). Spi-B belongs to the Ets family of transcription factors. It is expressed predominantly in B cells, T-cell progenitors, and plasmacytoid dendritic cells. Spi-B plays crucial roles in the development of T cells and plasmacytoid dendritic cells, and in the terminal differentiation of B cells. Although Spi-B deficient mice have normal numbers of B cells, they exhibit defects in germinal center formation and maintenance. In contrast, overexpression of Spi-B blocks plasma cell differentiation due to its capacity to repress Blimp-1 and Xbp-1 expression.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Flow Cytometry, Immunocytochemistry|
|SPI-B; Spib; Spi-1/PU.1 related; Ets transcription factor Spi-B|
|Mouse Spi-B Recombinant Protein|
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