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Spi-B Rat anti-Mouse, PE, Clone: U14-267, BD

Catalog No. BDB565834 Shop All BD Biosciences Products
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BDB565834 50 μg
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Catalog No. BDB565834 Supplier BD Biosciences Supplier No. 565834

Description

Rat Monoclonal Antibody

The U14-267 monoclonal antibody specifically recognizes mouse Spi-B, that is encoded by Spib (Spi-B transcription factor (Spi-1/PU.1 related)). Spi-B belongs to the Ets family of transcription factors. It is expressed predominantly in B cells, T-cell progenitors, and plasmacytoid dendritic cells. Spi-B plays crucial roles in the development of T cells and plasmacytoid dendritic cells, and in the terminal differentiation of B cells. Although Spi-B deficient mice have normal numbers of B cells, they exhibit defects in germinal center formation and maintenance. In contrast, overexpression of Spi-B blocks plasma cell differentiation due to its capacity to repress Blimp-1 and Xbp-1 expression.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Spi-B
Applications Flow Cytometry, Immunocytochemistry
Classification Monoclonal
Clone U14-267
Concentration 0.2mg/mL
Conjugate PE
Description SPI-B; Spib; Spi-1/PU.1 related; Ets transcription factor Spi-B
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse Spi-B Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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