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Invitrogen™ Rat Estrogen Receptor beta (aa 467-485) Synthetic Peptide

Catalog No. PEP007
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50 μg
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PEP007 50 μg
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Catalog No. PEP007 Supplier Invitrogen™ Supplier No. PEP007
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Description

Synthetic Peptide

Rat Estrogen Receptor beta (residues 467-485) Synthetic Peptide, PEP-007, from Invitrogen.

Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.
TRUSTED_SUSTAINABILITY

Specifications

Gene ID (Entrez) 25149
Species Rat
Purification Method purified
Accession Number Q62986
Common Name Rat Estrogen Receptor beta (aa 467-485)
Concentration 0.5 mg/mL
Content And Storage -20°C. Avoid freeze-thaw cycles.
Description Synthetic Peptide
Format Lyophilized
Formulation peptide with no preservative
For Use With (Application) Control
Gene Symbol Esr2
Lyophilized Lyophilized
Preservative No preservative
Product Type Peptide
Quantity 50 μg
Regulatory Status RUO - research use only
Sequence C - S - S - T - E - D - S - K - N - K - E - S - S - Q - N - L - Q - S - Q
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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