Gibco™ Rat Fractalkine (CX3CL1) Recombinant Protein, PeproTech®

Catalog No.	Quantity
40026250UG	250 μg
40026100UG	100 μg
400-26-1MG	1 mg
400-26-20UG	20 μg
40026500UG	500 μg
400-26-5UG	5 μg

Catalog No. 40026250UG Supplier Gibco™ Supplier No. 40026250UG

Description

Recombinant Protein

Recombinant Recombinant Rat Fractalkine is an 8.7 kDa protein containing 76 amino acid residues, including the four conserved cysteine residues present in CC chemokines. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.

Specifications

• Accession Number: O55145
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 89808
• Molecular Weight (g/mol): 8.7 kDa
• Name: Rat Fractalkine (CX3CL1)
• Quantity: 250 μg
• Source: E. coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: A-152E5.2; AB030188; ABCD-3; Acc1; AI848747; C3Xkine; chemokine (C-X3-C motif) ligand 1; CX3C; CX3C membrane-anchored chemokine; C-X3-C motif chemokine 1; C-X3-C motif chemokine ligand 1; Cx3cl1; CXC3; CXC3C; D8Bwg0439e; Fkn; Fractalkine; neurotactin; NTN; NTT; Processed fractalkine; SCYD1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D, 1; small-inducible cytokine D1
• Common Name: CX3CL1
• Gene Symbol: Cx3cl1
• Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 5.0-10.0 ng/ml
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: QHLGMTKCNI TCHKMTSPIP VTLLIHYQLN QESCGKRAII LETRQHRHFC ADPKEKWVQDAMKHLDHQTA ALTRNG
• Content And Storage: -20°C
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.