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Invitrogen™ eBioscience™ Rat IL-1 beta Platinum ELISA Kit Non-distribution product as customer accommodation.

For the quantitative detection of rat IL-1beta.

Manufacturer:  Invitrogen™ BMS630

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Catalog No. 50-112-5471


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Includes: Aluminium pouch(es) with a Microwell Plate coated with polyclonal antibody to rat IL-1beta
Biotin-Conjugate anti-rat IL-1beta polyclonal antibody
Streptavidin-HRP
Rat IL-1beta Standard lyophilized, 4ng/mL upon reconstitution
Sample Diluent
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

Description

Description

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
Specifications

Specifications

Q63264
Biotin
24494
Adhesive Plate Covers
96 tests
4.0 pg/mL
50μL
Rat
1 hr 20 min
Rat
Catabolin, Interleukin-1 beta, IL1F2
10%
31.3-2,000 pg/mL
ELISA
Colorimetric Microplate Reader
ELISA Kit
RUO
Serum,Supernatant
Serum,50 μL|Supernatant,50 μL
2-8°C
3 hr 10 min
Il1b
10%
HRP
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