Gibco™ Rat IL-6 Recombinant Protein, PeproTech®

Catalog No.	Quantity
40006100UG	100 μg
400-06-10UG	10 μg
40-006-01M	2 x 500 μg
400-06-2UG	2 μg
40006500UG	500 μg
400-06-50UG	50 μg
40006250U	250 μg

Catalog No. 40006100UG Supplier Gibco™ Supplier No. 40006100UG

Description

Recombinant Protein

400-06-1MG will be provided as 2 x 500 μg (400-06-500UG). Recombinant Rat IL-6 is a 21.7 kDa protein containing 188 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.

Specifications

• Accession Number: P20607
• For Use With (Application): Control, Western Blot Control, ELISA Standard, Bioactivity
• Formulation: Protein with no preservative
• Gene ID (Entrez): 24498
• Molecular Weight (g/mol): 21.7 kDa
• Name: Rat IL-6
• Purification Method: Purified
• Quantity: 100 μg
• Source: E. coli
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/μg
• Gene Alias: B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6
• Common Name: IL-6
• Gene Symbol: Il6
• Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7 TD1 cells is ≤ 0.01 ng/ml, corresponding to a specific activity of ≥ 1 x 10^8 units/mg
• Product Type: Protein
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: MFPTSQVRRG DFTEDTTHNR PVYTTSQVGG LITYVLREIL EMRKELCNGN SDCMNSDDAL SENNLKLPEI QRNDGCFQTG YNQEICLLKI CSGLLEFRFY LEFVKNNLQD NKKDKARVIQ SNTETLVHIF KQEIKDSYKI VLPTPTSNAL LMEKLESQKE WLRTKTIQLI LKALEEFLKV TMRSTRQT
• Content And Storage: -20°C
• Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is ≤ 0.01 ng/ml, corresponding to a specific activity of ≥ 1 x 10^8 units/mg.
• Expression System: E. coli
• Form: Lyophilized
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.