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Rb Monoclonal Antibody (1F8 (Rb1)), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA511387

Catalog No. PIMA511387


Description

Description

MA5-11387 targets Retinoblastoma in FACS, ICC/IF, IHC (P), IP, and WB applications and shows reactivity with human and mouse samples. Does not react with rat samples. The MA5-11387 immunogen is recombinant human Rb protein.

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Rb
Monoclonal
0.2 mg/mL
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
P06400, P13405
RB1
Recombinant human Rb protein
500 μL
Primary
Human, Mouse
Antibody
IgG1
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
1F8 (Rb1)
Unconjugated
RB1
Cleaved Rb; delta RB-p70; DRb-p70; exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; OSRC; p104; p104 chicken Rb; P105RB; p105-Rb; Phospho-Retinoblastoma; pp105; pp110; PPP1R130; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; rb; RB transcriptional corepressor 1; RB1; Rb-1; Rb-p70; Retin; Retinoblastoma; retinoblastoma 1; retinoblastoma 1 (including osteosarcoma); retinoblastoma 1 protein; retinoblastoma gene; retinoblastoma isoform A; retinoblastoma protein; retinoblastoma suspectibility protein; retinoblastoma tumor suppressor; retinoblastoma-associated protein
Mouse
Protein G
RUO
19645, 5925
4° C
Liquid
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