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RBP2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. 501732244 Shop All Proteintech Group Inc Products
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50-173-2244 150 μL
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Catalog No. 50-173-2244 Supplier Proteintech Group Inc Supplier No. 188251AP150UL
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Description

Rabbit Polyclonal Antibody

UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctionsThis gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

Specifications

Antigen RBP2
Applications Immunocytochemistry, Immunofluorescence, Western Blot
Classification Polyclonal
Concentration 0.24 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene KDM5A
Gene Accession No. P29375, Q3UXZ9
Gene Alias Histone demethylase JARID1A, JARID1A, KDM5A, lysine (K) demethylase 5A, Lysine specific demethylase 5A, RBBP 2, RBBP2, RBP2
Gene Symbols Kdm5a
Host Species Rabbit
Immunogen Peptide
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 214899, 312678, 5927
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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