Invitrogen™ REA Monoclonal Antibody (2B5)

Catalog No.	Quantity
PIMA549251	100 μg

Catalog No. PIMA549251

Supplier: Invitrogen™ MA549251

Description

Mouse Monoclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human Hela whole cell, human HEK293 whole cell, rat brain tissue, rat heart tissue, rat liver tissue, mouse brain tissue, mouse heart tissue, mouse liver tissue. IHC: human gallbladder adenocarcinoma tissue, human ovarian serous adenocarcinoma tissue, human renal clear cell carcinoma tissue, human lung cancer tissue, mouse colon tissue, rat colon tissue. Flow: HepG2 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging.

Specifications

• Antigen: REA
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 2B5
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and no preservative
• Gene: PHB2
• Gene Accession No.: O35129, Q5XIH7, Q99623
• Gene Alias: AU044498; BAP; Bap37; Bap-37; Bcap27; BCAP37; B-cell associated protein; B-cell receptor associated protein 37; B-cell receptor-associated protein 37; B-cell receptor-associated protein BAP37; D-prohibitin; hBAP; MGC117268; p22; phb2; phb2 {ECO:0000250; PNAS-141; prohibitin 2; prohibitin-2; Rea; Repressor of estrogen receptor activity; UniProtKB:Q99623}
• Gene Symbols: PHB2
• Host Species: Mouse
• Immunogen: E.coli-derived human REA/PHB2 recombinant protein (Position: M1-K299).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 11331, 114766, 12034
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG2b