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Apexbio Technology LLC TNF-alpha/TNFSF2，human recombinant protein 500ug
Supplier: Apexbio Technology LLC P12440.5
Tumor necrosis factor-alpha (TNF- ) a cytokine belonging to the TNF superfamily is primarily produced by activated macrophages neutrophils lymphocytes NK cells endothelial cells and several transformed cell types It exists biologically as both membrane-bound and soluble homotrimeric forms interacting with two distinct receptors (TNFR1 and TNFR2) to mediate apoptotic or proliferative signaling pathways including NF- B and MAPK cascades Due to its central involvement in apoptosis inflammation immune regulation and cell differentiation recombinant human TNF- proteins have extensive applications in biomedical research such as studies on autoimmune disorders inflammation oncology and immunomodulation For instance human TNF- recombinant protein (UniProt P01375 Val77-Leu233) expressed with His-tag in E coli is frequently employed in vitro for investigating cytokine receptor signaling pathways and immune cell-mediated responses
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