R&D Systems™ Recombinant Human Active SHP-2 Protein

Description

Extensive quality control produces industry leading bioactivity and lot-to-lot consistency that instills confidence in results and ensures reproducibility. Applications: Enzyme Activity

Measured by its ability to dephosphorylate a tyrosine residue in a peptide containing the EGFR Y992 phosphorylation site (Catalog # ES006 ). The specific activity is >3 μmol/min/mg, measured under the described conditions.

Specifications

• Accession Number: NP_002825.3
• Characterization: Enzyme Activity
• For Use With (Application): Enzyme Activity
• Formulation: Supplied as a 0.2 μm filtered solution in Tris, NaCl, Glycerol and DTT.
• Gene ID (Entrez): 5781
• Molecular Weight (g/mol): M.W. (Observed): 63-70 kDa, reducing conditions; M.W. (theoretical): 69 kDa
• Quantity: 1 mg
• Source: E. coli-derived human SHP-2 protein Thr2-Arg593, with an N-terminal 6-His tag
• Storage Requirements: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70°C as supplied. 3 months, -70°C under sterile conditions after opening.
• Endotoxin Concentration: <1.0 EU / 1 μg of the protein by the LAL method.
• Gene Alias: BPTP3, EC 3.1.3.48,mgC14433, protein tyrosine phosphatase, non-receptor type 11, protein tyrosine phosphatase-2, Protein-tyrosine phosphatase 1D, Protein-tyrosine phosphatase 2C, PTP1D, PTP-1D, PTP2C, PTP-2C, PTP2CNS1, PTPN11, SHP2, SHP-2, SHP2CFC, SHPTP2, SH-PTP2, SH-PTP2Noonan syndrome 1, SH-PTP3, tyrosine-protein phosphatase non-receptor type 11
• Gene Symbol: PTPN11
• Product Type: Recombinant Protein
• Conjugate: Unconjugated
• Species: Human
• Purity or Quality Grade: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Protein: SHP-2/PTPN11