R&D Systems™ Recombinant Human CLEC2L Fc Chimera Protein

Description

C-type lectin domain family 2, member L (CLEC2L), is a type II transmembrane protein of the CLEC2 family of proteins that includes CD69, LLT1, AICL and KACL

• CLEC2 family members have broad tissue expression, with LLT1, AICL and KACL expressed on B cells, monocytes, and keratinocytes, respectively
• In contrast, CLEC2L, a homodimeric cell surface receptor, is predominantly expressed in the brain and is referred to as the brain-associated C-type lectin (BACL)
• Mature human CLEC2L includes a 68 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 125 aa extracellular domain (ECD).
• Within the ECD, human CLEC2L shares 94% aa sequence identity with mouse and rat CLEC2L.

Specifications

• Accession Number: P0C7M8-1
• For Use With (Application): Bioactivity
• Gene ID (Entrez): 154790
• Molecular Weight (g/mol): 41 kDa
• Purification Method: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie™ Blue Staining
• Quantity: 50 μg
• Source:

  Human embryonic kidney cell, HEK293-derived human CLEC2L protein

  MDHuman IgG2A (Pro100-Lys333)IEGRHuman CLEC2L (Ser90-Thr214) Accession # P0C7M8-1N-terminus C-terminus

• Storage Requirements: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
• Endotoxin Concentration: <0.10 EU per 1 μg of the protein by the LAL method
• Conjugate: Unconjugated
• Reconstitution: Reconstitute at 500 μg/mL in PBS
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS