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R&D Systems™ Recombinant Human DLL4 Fc Chimera Protein

Catalog No. 10185D4050
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Quantity:
50 μg
This item is not returnable. View return policy
This item is not returnable. View return policy

Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands

  • Notch signaling is an evolutionarily conserved pathway that controls cell fate and is required in multiple developmental processes including vascular development, hematopoiesis, somatogenesis, myogenesis, and neurogenesis
  • Dysregulation in the Notch pathway is associated with various human diseases
  • Measured by the ability of the immobilized protein to enhance BMP-2 induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. The ED50 fort his effect is 0.02-0.12 μg/mL.

Specifications

Accession Number Q9NR61
For Use With (Application) Bioactivity
Gene ID (Entrez) 54567
Molecular Weight (g/mol) 81 kDa
Purification Method >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie™ Blue Staining
Quantity 50 μg
Source

Human embryonic kidney cell, HEK293-derived human DLL4 protein

Human DLL4 (Ser27-Pro524) Accession # Q9NR61IEGRMDPHuman IgG1 (Pro100-Lys330)N-terminus C-terminus

Storage Requirements Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
Endotoxin Concentration <0.10 EU per 1 μg of the protein by the LAL method
Conjugate Unconjugated
Reconstitution Reconstitute at 250 μg/mL in PBS
Buffer Lyophilized from a 0.2 μm filtered solution in PBS
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