R&D Systems™ Recombinant Human NCAM-1/CD56 Fc Chimera Protein

Catalog No.	Quantity
10-136-NC050	50 μg

Catalog No. 10-136-NC050 Supplier R&D Systems™ Supplier No. 10136NC050

Description

Neural cell adhesion molecule 1 (NCAM-1), also known as CD56, is a multifunctional member of the Ig superfamily

• It belongs to a family of membrane-bound glycoproteins that are involved in Ca⁺⁺ independent cell matrix and homophilic or heterophilic cell-cell interactions.
• NCAM-1 in the adult brain shows a decline of sialylation relative to earlier developmental periods.
• In regions that retain a high degree of neuronal plasticity, however, the adult brain continues to express polysialylated-NCAM-1, suggesting sialylation of NCAM-1 is involved in regenerative processes and synaptic plasticity
• NCAM can function as a receptor for GDNF family of ligands. GDNF stimulates Schwann cell migration and neurite outgrowth in hippocampal and cortical neurons through binding to NCAM-1 and activation of Fyn, independently of RET
• NCAM-1 also interacts with Ig IIIC isoform of the FGFR1 and plays an important role in developmental events as well as tumor progression
• Due to expression on immune cells NCAM-1 has great implications on tumor progression, infection, and disease development

Specifications

• Accession Number: P13591-1
• For Use With (Application): Bioactivity
• Gene ID (Entrez): 4684
• Molecular Weight (g/mol): 103 kDa
• Purification Method: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie™ Blue Staining
• Quantity: 50 μg
• Source:

  Human embryonic kidney cell, HEK293-derived human NCAM-1/CD56 protein

  Human NCAM-1/CD56 (Leu20-Gly708) Accession # P13591-1IEGRMDHuman IgG1 (Pro100-Lys330)N-terminus C-terminus

• Storage Requirements: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 2 weeks, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
• Endotoxin Concentration: <0.10 EU per 1 μg of the protein by the LAL method
• Conjugate: Unconjugated
• Reconstitution: Reconstitute at 500 μg/mL in PBS
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS