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R&D Systems™ Recombinant Human OX40 Ligand/TNFSF4 Protein

Catalog No. 1054OX025
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25 μg
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Catalog No. Quantity
10-54O-X025 25 μg
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Catalog No. 10-54O-X025 Supplier R&D Systems™ Supplier No. 1054OX025
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Description

Recombinant Protein

Measured by its ability to induce IL-8 secretion in HT1080 human fibrosarcoma cells transfected with human OX40/TNFRSF4. Muller, N. et al. (2008) FEBS J. 275:2296. The ED50 for this effect is typically 1-5 ng/mL. Measured by its binding ability in a functional ELISA. When Recombinant Human OX40/TNFRSF4 Fc Chimera (Catalog # 3388-OX ) is immobilized at 10 ng/mL, the concentration of Recombinant Human OX40 Ligand/TNFSF4 that produces 50% optimal binding response is found to be approximately 0.5-3 ng/mL.

Specifications

Accession Number Q6FGS4
For Use With (Application) Bioactivity, Binding Activity
Formulation Supplied as a 0.2 μm filtered solution in PBS.
Gene ID (Entrez) 7292
Molecular Weight (g/mol) M.W.-observed: 28-34 kDa, reducing conditions, M.W.-theroretical: 18 kDa
Quantity 25 μg
Source Mouse myeloma cell line, NS0-derived human OX40 Ligand/TNFSF4 protein MHHHHHHHHHH GGGSGGGSGGGS IEGR Human OX40 Ligand (Gln51-Leu183) (N-terminus) Accession # Q6FGS4 (C-terminus)
Storage Requirements Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20°C to -70°C as supplied. 1 month, 2°C to 8°C under sterile conditions after opening.
Endotoxin Concentration <1.0 EU / 1 μg of the protein by the LAL method.
Gene Alias CD134 ligand, CD134L, CD252, CD252 antigen, Glycoprotein Gp34, gp34, O x 40 antigen ligand, O x 40 ligand, O x 40 L, OX-40 L, O x 4 OL, TAX transcriptionally-activated glycoprotein 1, tax-transcriptionally activated glycoprotein 1 (34 kD), tax-transcriptionally activated glycoprotein 1, 34 kD, TNFSF4, tumor necrosis factor (ligand) superfamily, member 4, tumor necrosis factor ligand superfamily member 4, TXGP1
Gene Symbol TNFSF4
Conjugate Unconjugated
Purity or Quality Grade >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Protein OX40 Ligand/TNFSF4
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