R&D Systems™ Recombinant Human Proprotein Convertase 9/PCSK9 Protein

Description

Extensive quality control produces industry leading bioactivity and lot-to-lot consistency that instills confidence in results and ensures reproducibility. Applications: Bioactivity

Measured by its binding ability in a functional ELISA. When Recombinant Human LDL R (Catalog # 2148-LD ) is coated at 2 μg/mL, Recombinant Human Proprotein Convertase 9/PCSK9 binds with an ED50 of 70-420 ng/mL.

Specifications

• Accession Number: Q8NBP7
• For Use With (Application): Bioactivity
• Formulation: Supplied as a 0.2 μm filtered solution in Tris, NaCl and Glycerol.
• Gene ID (Entrez): 255738
• Molecular Weight (g/mol): M.W. (Observed): 19 kDa & 66 kDa, reducing conditions; M.W. (theoretical): 14 kDa & 59 kDa
• Name: Proprotein Convertase 9/PCSK9
• Quantity: 10 μg
• Source: Mouse myeloma cell line, NS0-derived human Proprotein Convertase 9/PCSK9 protein Gln31-Gln152 & Ser153-Gln692, with a C-terminal 10-His tag
• Storage Requirements: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20°C to -70°C as supplied. 3 months, -20°C to -70°C under sterile conditions after opening.
• Structural Form: Mature form & pro domain
• Endotoxin Concentration: <1.0 EU / 1 μg of the protein by the LAL method.
• Gene Alias: EC 3.4.21, EC 3.4.21.111, FH3, FH3neural apoptosis regulated convertase 1, FHCL3, HCHOLA3, hypercholesterolemia, autosomal dominant 3, LDLCQ1, NARC1, NARC-1, NARC-1convertase subtilisin/kexin type 9 preproprotein, NARC1EC 3.4.21.-, Neural apoptosis-regulated convertase 1, PC9, PCSK9, Proprotein convertase 9, proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9
• Gene Symbol: PCSK9
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Purity or Quality Grade: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie™ Blue Staining.
• Protein: Proprotein Convertase 9/PCSK9