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R&D Systems™ Recombinant Human TNF-alpha Hyperactive Mutant Protein

Catalog No. 8599TA010
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8599TA010 10 μg
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Description

Extensive quality control produces industry leading bioactivity and lot-to-lot consistency that instills confidence in results and ensures reproducibility.

The Recombinant Human TNF-alpha Hyperactive Mutant Protein is derived from E. coli. The Recombinant Human TNF-alpha Hyperactive Mutant Protein has been validated for the following applications: Bioactivity.

Specifications

Accession Number P01375
For Use With (Application) Bioactivity
Gene ID (Entrez) 7124
Molecular Weight (g/mol) Observed M.W.: 16kDa, reducing conditions, Theoretical M.W.: 17kDa
Quantity 10 μg
Source E. coli-derived human TNF-alpha protein Lys87-Leu233 (Leu233Phe),with an N-terminal Met-Arg-Lys-Arg
Storage Requirements Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70° C as supplied. 1 month, 2 to 8° C under sterile conditions after reconstitution. 3 months, -20 to -70° C under sterile conditions after reconstitution.
Endotoxin Concentration <0.10 EU per 1μg of the protein by the LAL method.
Gene Alias APC1 protein, Cachectin, Cachetin, DIF, TNF, TNF, monocyte-derived, TNF-a, TNFA, TNFalpha, TNF-alphacachectin, TNFATNF, macrophage-derived, TNFG1F, TNFSF1A, TNFSF2, TNFSF2TNF superfamily, member 2, tumor necrosis factor, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, Tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
Common Name TNF-alpha
Gene Symbol TNF
Biological Activity Measured in a cytotoxicity assay using L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. Matthews, N. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 221. The ED50 for this effect is typically 2.5-12.5 pg/mL.
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Expression System E. coli-derived Lys87-Leu233 (Leu233Phe), with an N-terminal Met-Arg-Lys-Arg
Purity or Quality Grade >95%, by SDS-PAGE with Silver Staining
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