R&D Systems™ Recombinant Human TSHR Fc Chimera Protein

Description

Extensive quality control produces industry leading bioactivity and lot-to-lot consistency that instills confidence in results and ensures reproducibility.

The Recombinant Human TSH R Fc Chimera Protein is derived from CHO. The Recombinant Human TSH R Fc Chimera Protein has been validated for the following applications: Bioactivity.

Specifications

• For Use With (Application): Bioactivity
• Gene ID (Entrez): 7253
• Molecular Weight (g/mol): Theoretical M.W.: 71kDa
• Name: TSHR
• Quantity: 50μg
• Source: Chinese Hamster Ovary cell line,CHO-derived human TSH R protein, (N-terminus) Human TSH R (Met22-Gly413) Accession &Num; P16473 IEGRMD Human IgG1 (Pro100-Lys330) (C-terminus)
• Storage Requirements: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70° C as supplied. 1 month, 2 to 8° C under sterile conditions after reconstitution. 3 months, -20 to -70° C under sterile conditions after reconstitution.
• Endotoxin Concentration: <0.10 EU per 1μg of the protein by the LAL method.
• Gene Alias: CHNG1, LGR3, LGR3hTSHR-I, MGC75129, seven transmembrane helix receptor, thyroid stimulating hormone receptor, Thyroid-stimulating hormone receptor, thyrotropin receptor, thyrotropin receptor-I, hTSHR-I, TSH R, TSH-R
• Common Name: TSH R
• Gene Symbol: TSHR
• Biological Activity: Measured by its ability to inhibit rhTSH-induced cAMP accumulation in HEK293 human embryonic kidney cells transfected with human TSH R. The ED50 for this effect is typically 2-12μg/mL.
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Expression System: Chinese Hamster Ovary cell line, CHO-derived Human TSH R (Met22-Gly413) Accession # P16473, N-terminus; IEGRMD; Human IgG1 (Pro100-Lys330), C-terminus
• Purity or Quality Grade: >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie™ Blue Staining