R&D Systems™ Recombinant Rat Lymphotoxin beta R/TNFRSF3 Fc Chimera

Description

Extensive quality control produces industry leading bioactivity and lot-to-lot consistency that instills confidence in results and ensures reproducibility.

The Recombinant Rat Lymphotoxin beta R/TNFRSF3 Fc Chimera is derived from NS0. The Recombinant Rat Lymphotoxin beta R/TNFRSF3 Fc Chimera has been validated for the following applications: Bioactivity.

Specifications

• For Use With (Application): Bioactivity
• Gene ID (Entrez): 4055
• Molecular Weight (g/mol): Observed M.W.: 60-68kDa, reducing conditions, Theoretical M.W.: 49kDa
• Quantity: 50 μg
• Source: Mouse myeloma cell line,NS0-derived rat Lymphotoxin beta R/TNFRSF3 protein, (N-terminus) Rat Lymphotoxin beta R (Gln29-Met222) Accession &Num; NP_001008316 IEGRMDP Mouse IgG2a (Glu98-Lys330) (C-terminus)
• Storage Requirements: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70° C as supplied. 1 month, 2 to 8° C under sterile conditions after reconstitution. 3 months, -20 to -70° C under sterile conditions after reconstitution.
• Endotoxin Concentration: <0.10 EU per 1μg of the protein by the LAL method.
• Gene Alias: CD18, D12S370, ltbetar, LT-BETA-R, LTBR, lymphotoxin B receptor, lymphotoxin beta receptor (TNFR superfamily, member 3), Lymphotoxin-beta receptor, LymphotoxinbR, TNF RIII, TNF Rrp, TNFCRTNF-RIII, TNFR superfamily, member 3, TNFR2-RP, TNFR3, TNF-R-III, TNFR-RP, TNFRSF3, TNFRSF3TNFR-III, Tumor necrosis factor C receptor, Tumor necrosis factor receptor 2-related protein, tumor necrosis factor receptor superfamily member 3, tumor necrosis factor receptor superfamily, member 3, Tumor necrosis factor receptor type III
• Common Name: Lymphotoxin beta R/TNFRSF3
• Gene Symbol: Ltbr
• Biological Activity: Measured by its ability to inhibit Lymphotoxin alpha 1/beta 2-induced IL-8 secretion in A375 human melanoma cells. Degli-Esposti, M. et al. (1997) J. Immunol. 158:1756. The ED50 for this effect is typically 0.15-0.9μg/mL.
• Conjugate: Unconjugated
• Species: Rat
• Recombinant: Recombinant
• Expression System: Mouse myeloma cell line, NS0-derived Rat Lymphotoxin beta R (Gln29-Met222) Accession # NP_001008316, N-terminus; IEGRMDP; Mouse IgG2a (Glu98-Lys330), C-terminus
• Purity or Quality Grade: >95%, by SDS-PAGE with Silver Staining