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  6. Invitrogen™ RELM alpha Monoclonal Antibody (DS8RELM), PerCP-eFluor™ 710, eBioscience™, Invitrogen™ 

Invitrogen™ RELM alpha Monoclonal Antibody (DS8RELM), PerCP-eFluor™ 710, eBioscience™, Invitrogen™
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Catalog No. 46544182
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46-544-182 100 μg
46-544-180 25 μg
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Catalog No. 46-544-182 Supplier Invitrogen™ Supplier No. 46544182
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Description

Rat Monoclonal Antibody

RELM alpha, also known as Resistin-like alpha or FIZZ1, is a small cytokine (88 aminoacids, MW 9.4 kDa) produced mostly by macrophages. Its highest constitutive expression has been observed in small peritoneal macrophages, alveolar macrophages and adipose tissue macrophages. It is strongly induced by IL-4 and IL-13. Together with Arginase 1 and Ym-1, RELM alpha is considered one of the hallmarks of the M2 polarization of mouse macrophages, however, macrophages polarized with IL-10 (M2c) express neither RELM alpha nor Arginase 1. Also, the expression patterns of RELM alpha and Arginase 1 in untreated tissue macrophages significantly differ. Elevated levels of RELM alpha may indicate parasitic infection. Humans do not have RELM alpha gene but human Resistin resembles mouse RELM alpha in respect to sequence, tissue distribution and function. Other members of RELM family in mouse: RELM beta, RELM gamma and Resistin display different tissue distribution and functional properties. RELM alpha plays an important role in parasite infection, mucosal inflammation and allergy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RELM alpha
Applications Flow Cytometry
Classification Monoclonal
Clone DS8RELM
Concentration 0.2 mg/mL
Conjugate PerCP-eFluor 710
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Retnla
Gene Accession No. Q9EP95
Gene Alias 1810019L16Rik; cysteine-rich secreted protein A12-gamma; Cysteine-rich secreted protein FIZZ1; Fizz1; Fizz-1; FIZZ2; found in inflammatory zone 1; Himf; HXCP2; Hypoxia-induced mitogenic factor; parasite-induced macrophage novel gene 1 protein; Pmng1; RELMa; RELMalpha; RELM-alpha; RELMb; RELMbeta; RELM-beta; resistin like alpha; resistin-like alpha; Retnla; Xcp2
Gene Symbols Retnla
Host Species Rat
Immunogen Recombinant mouse RELM alpha protein.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57262
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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