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Apexbio Technology LLC Repaglinide 135062-02-1 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A53165.1

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Repaglinide (CAS 135062-02-1) is a small-molecule modulator that acts as a blocker of ATP-sensitive potassium (K sub ATP /sub ) channels specifically binding with high affinity to the sulfonylurea receptor 1 (SUR1) subunit when co-expressed with K sub ir /sub 6 2 (K sub d /sub 0 42 nM) Through inhibition of K sub ATP /sub channel activity repaglinide promotes membrane depolarization and subsequent insulin secretion from pancreatic -cells In vivo studies demonstrate its glucose-lowering (hypoglycaemic) effects supporting its utility in antidiabetic research and in mechanistic investigations of pancreatic K sub ATP /sub channel regulation

Catalog No. 50-000-96957


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