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Apexbio Technology LLC ML241 1346528-06-0 25mg
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Supplier:  Apexbio Technology LLC B610725

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ML241 (CAS 1346528-06-0) is a potent and selective inhibitor of the p97 ATPase (also known as valosin-containing protein VCP) an AAA family ATPase involved in diverse cellular processes including degradation of misfolded proteins membrane fusion protein aggregate regulation and autophagosome maturation ML241 exhibits an in vitro IC50 of approximately 100 nM for p97 inhibition In cellular models ML241 impedes the degradation of p97-dependent but not p97-independent proteasomal substrates and disrupts the endoplasmic reticulum-associated degradation (ERAD) pathway Currently ML241 is utilized in preclinical research to investigate p97-related cellular mechanisms in cancer and neurodegenerative disease contexts

Catalog No. 50-000-91988


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