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Tocris Bioscience™ Reversan
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Catalog No. 372210R
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Catalog No. Quantity
37-221-0R 10 mg
37-225-0R 50 mg
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Catalog No. 37-221-0R Supplier Tocris Bioscience™ Supplier No. 3722/10
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Description

Selective MRP1 and P-gp inhibitor

Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin (Cat. No. 2252), vincristine (Cat. No. 1257) and etoposide (Cat. No. 1226) by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo. Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates.

Specifications

Quantity 10 mg
Product Type Reversan
Purity 0.95
Molecular Weight (g/mol) 441.52
Inhibitors Reversan

For Research Use Only

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