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RFWD3 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501560276
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Catalog No. Quantity
50-156-0276 100 μL
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Catalog No. 50-156-0276 Supplier Bethyl Laboratories, Inc Supplier No. A301396A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair. {ECO:0000269; PubMed:20173098, ECO:0000269; PubMed:21504906, ECO:0000269; PubMed:21558276}.

Specifications

Antigen RFWD3
Applications Immunoprecipitation
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene RFWD3
Gene Accession No. Q6PCD5
Gene Alias RNF201, E3 ubiquitin-protein ligase RFWD3, RING finger and WD repeat domain-containing protein 3, RING finger protein 201
Gene Symbols RFWD3
Host Species Rabbit
Immunogen Between 75 and 125
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55159
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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