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  6. RHBDD1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech 

RHBDD1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. 501733127 Shop All Proteintech Group Inc Products
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50-173-3127 150 μL
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Catalog No. 50-173-3127 Supplier Proteintech Group Inc Supplier No. 208691AP150UL
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Description

Rabbit Polyclonal Antibody

The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD1 is highly expressed in the testis and is involved in the cleavage of BIK, a proapoptotic member of the Bcl-2 family. Overexpression or suppression by RNAi of RHBDD1 in 293 cells will reduce or enhance BIK-mediated apoptosis, respectively, demonstrating that RHBDD1 modulates BIK-mediated apoptotic activity. In GC-1 cells, a spermatogonia cell line that can differentiate into spermatids within the seminiferous tubules, suppression of RHBDD1 expression by RNAi caused the cells to lose the ability to survive and differentiate in mouse seminiferous tubules, suggesting that RHBDD1 may be associated with mammalian spermatogenesis.

Specifications

Antigen RHBDD1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.21 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene RHBDD1
Gene Accession No. Q4V8F3, Q8BHC7, Q8TEB9
Gene Alias HSD 50, RHBDD1, rhomboid domain containing 1
Gene Symbols Rhbdd1
Host Species Rabbit
Immunogen RHBDD1 Fusion Protein Ag14932
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 316557, 76867, 84236
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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