Invitrogen™ RhoBTB1/RhoBTB2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536326

Catalog No. PIPA536326

Description

This antibody detects endogenous protein at a molecular weight of 83 kDa. Purity is >95% by SDS-PAGE.

RHOBTB1 (Rho-related BTB domain-containing protein 1) and RHOBTB3 (Rho-related BTB domain-containing protein 3) each contain two BTB (POZ) domains and belong to the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region, a GTPase domain and two tandem BTB repeats. While both RHOBTB1 and RHOBTB3 are expressed ubiquitously, RHOBTB1 is found at high levels in placenta, stomach, testis, kidney and skeletal muscle, whereas RHOBTB3 is found at high levels in neural and cardiac tissues. RHOBTB1 is thought to play a role in GTPase-mediated signaling and may participate in organization of the Actin filament system. Additionally, RHOBTB1 expression is decreased in head and neck carcinomas, suggesting a possible role for RHOBTB1 as a tumor suppressor.

Specifications

• Antigen: RhoBTB1/RhoBTB2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RHOBTB1
• Gene Alias: 1700008H16Rik; 3110048G13Rik; AI173445; AI573858; AV350930; DBC2; deleted in breast cancer 2 gene protein; Deleted in breast cancer 2 gene protein homolog; E130206H14Rik; KIAA0717; KIAA0740; mKIAA0717; p83; Rho related BTB domain containing 1; Rho related BTB domain containing 2; Rhobtb1; Rhobtb2; Rho-related BTB domain containing 1; Rho-related BTB domain containing 2; rho-related BTB domain-containing protein 1; Rho-related BTB domain-containing protein 2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23221, 246710, 306004, 309722, 69288, 9886
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O94844, Q91V93, Q9BYZ6, Q9DAK3
• Gene Symbols: RHOBTB1, RHOBTB2
• Immunogen: Synthetic peptide corresponding to amino acids 52-98 of human RhoBTB1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG