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Rifampin, MP Biomedicals™

Catalog No. MP021954902 Shop All MP Biomedicals, Inc Products
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MP021954902 250 mg
MP021954901 100 mg
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Description

Inhibits DNA-dependent bacterial RNA polymerase. Rifampin, MP Biomedicals is a bactericidal antibiotic drug of the rifamycin group that does not affect mammalian RNA polymerase. It is used to treat Tuberculosis and Tuberculosis-related mycobacterial infec

Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. It inhibits the assembly of DNA and protein into mature virus particles.

  • Treats Tuberculosis and Tuberculosis-related mycobacterial infections
  • Widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC)
  • It has been shown to cause hepatitis
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 13292-46-1
Molecular Formula C43H58N4O12
Molecular Weight (g/mol) 822.953
InChI Key FZYOVNIOYYPUPY-HRJPTAQKSA-N
Synonym Rifamycin AMP, Rifampicin, 3-(4-Methylpiperazinyliminomethyl)rifamycin SV, Rifampicin
PubChem CID 131839595
SMILES CC1C=CC=C(C(=O)NC2=C(C3=C(C(=C4C(=C3C(=O)C2=CNN5CCN(CC5)C)C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C

Specifications

Physical Form Powder
Absorbance λ max (methanol): 237–239, 334–338, 475–479nm
Melting Point 183°C to 188°C (decomposition)(literature)
Extinction Coefficient EmM (max absorbance, phosphate buffer, pH 7.38): 33.20 (237nm); 32.10 (255nm); 27.00 (334nm);15.40 (475nm) (Lit.)
Quantity 250 mg
Optical Rotation [α]D25°=+10.6° (c=0.5% in CDCl3)(Lit.)
Solubility Information Soluble in chloroform (349mg/mL, 25°C), DMSO (∽100mg/mL), ethyl acetate (108mg/mL, 25°C), methanol (16mg/mL, 25°C) tetrahydrofuran.
Formula Weight 822.96

Safety and Handling

Recommended Storage +4°C
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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