Rifamycin SV Sodium Salt, MP Biomedicals™

Description

Used to study potential genes that may be involved in the conversion of rifamycin SV into rifamycin B. Rifamycin SV Sodium Salt, MP Biomedicals is a broad-spectrum semisynthetic antimicrobial agent of the rifamycin group. It has limited oral absorption.

Rifamycin SV inhibits selective (E. coli, B. subtilis) bacterial DNA-dependent RNA polymerase by binding to the polymerase β-subunit, a mechanism similar to rifabutin. It acts as a selective cytochrome P450 3A4 inducer. It has limited oral absorption. It is active against Gram-positive bacteria and is moderately active against Gram-negative organisms.

• Used to study potential genes, such as rif15 and rif16, which may be involved in the conversion of rifamycin SV into rifamycin B
• Potential treatment for traveler’s diarrhea (TD), Clostridium difficile-associated disease (CDAD) and rheumatoid knee synovitis
• It is used in electron spin resonance studies

Specifications

Chemical Identifiers

• CAS: 14897-39-3
• Molecular Formula: C37H47NNaO12
• Molecular Weight (g/mol): 720.77
• MDL Number: MFCD09752825
• InChI Key: YVOFSHPIJOYKSH-DITFEXNXSA-N
• Synonym: rifamycin sodium salt, rifamycin sodium usan, rifamycin sv sodium salt, rifocina tn, otofa tn
• PubChem CID: 124219641
• IUPAC Name: sodium (7S,9Z,11S,12R,13S,14R,15R,16R,17S,18S,19Z,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1⁴,⁷.0⁵,²⁸]triaconta-1,3,5(28),9,19,21,25(29),26-octaen-13-yl acetate
• SMILES: [Na+].CO[C@H]1\C=C/O[C@@]2(C)OC3=C(C)C(O)=C4C(O)=C(NC(=O)\C(C)=C/C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C=C(O)C4=C3C2=O

• Quantity: 250 mg
• Solubility Information: Ethanol: soluble (50mg/mL)
• Formula Weight: 719.8
• Physical Form: Powder

Safety and Handling

Recommended Storage

+4°C. Store under nitrogen. Protect from light.

WARNING: Cancer - www.P65Warnings.ca.gov