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Ring1B Monoclonal Antibody (3-3), Active Motif™
SDP

Catalog No. p-7188816
Encompass
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Catalog No. Quantity
50-199-2771 10 μg
50-227-7227 50 μg
50-199-2770 100 μg
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Catalog No. 50-199-2771 Supplier Active Motif Supplier No. 39664
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Description

Mouse Monoclonal Antibody

RNF2 (E3 ubiquitin-protein ligase RING2) is a ligase that mediates monoubiquitination of Lys-119 of histone H2A (H2AK119Ub). Therefore, it plays a central role in histone code and gene regulation. The ligase activity is enhanced by BMI1/PCGF4. H2AK119Ub gives a specific tag for epigeneti transcriptional repression and participates in X chromosome inactivation of female mammals. RNF2 may be involved in the initiation of both imprinted and random X inactivation. RNF2 is also an essential component of a Polycomb group (PcG) multiprotein PRC1-like complex. This complex class is required to maintain the transcriptionally repressive state of many genes including Hox genes throughout development. The PcG PRC1 complex acts via chromatin remodeling and modification of histones and rendering chromatin heritably changed in its expressibility.

Specifications

Antigen Ring1B
Applications ChIP Assay, ChIP sequencing (ChIP-seq)
Classification Monoclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene RNF2
Gene Accession No. Q99496, Q9CQJ4
Gene Alias AI326319; AI450156; AU019207; BAP 1; BAP1; BAP-1; BOS_16138; DING; DinG protein; E3 ubiquitin-protein ligase RING2; fa19h05; GS1-120K12.1; HIP2-interacting protein 3; HIPI 3; HIPI3; Huntingtin-interacting protein 2-interacting protein 3; OTTHUMP00000060668; Protein DinG; RING 1B; RING 2; RING finger protein 1B; RING finger protein 2; RING finger protein BAP-1; RING1B; RING2; RING-type E3 ubiquitin transferase RING2; RNF 2; RNF2; wu:fa19h05; wz4556; wz4566
Gene Symbols RNF2
Host Species Mouse
Immunogen This Ring1B antibody was raised against the recombinant full-length mouse protein.
Purification Method Protein G
Quantity 10 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19821, 6045
Target Species Human, Monkey, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b
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