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Invitrogen™ RIP3 Polyclonal Antibody
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Catalog No. PIPA519956 Shop All Thermo Scientific Products
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PIPA519956 100 μg
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Catalog No. PIPA519956 Supplier Invitrogen™ Supplier No. PA519956
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Description

Rabbit Polyclonal Antibody

Suggested positive controls are Rat Thymus Lysate, 3T3/NIH Cell Lysate, or C2C12 Cell Lysate. PA5-19956 can be used with blocking peptide PEP-0081.

RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, which contains a C-terminal domain unique from other RIP family members. RIPK3 is predominantly localized to the cytoplasm, and specifically, are colocalized in the mitochondrion which can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. RIPK3 is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor and caspase-8 prevents RIPK3-dependent necrosis without inducing apoptosis by functioning in a proteolytically active complex with CFLAR and that this complex is required for the protective function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RIP3
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene RIPK3
Gene Accession No. Q9QZL0, Q9Z2P5
Gene Alias 2610528K09Rik; AW107945; Hcyp2; Homocysteine respondent protein HCYP2; mRIP3; receptor interacting protein 3; receptor interacting serine/threonine kinase 3; receptor-interacting protein 3; receptor-interacting serine/threonine-protein kinase 3; receptor-interacting serine-threonine kinase 3; Rip3; RIP-3; Ripk3; RIP-like protein kinase 3
Gene Symbols RIPK3
Host Species Rabbit
Immunogen A peptide corresponding to 14 amino acids near the carboxy terminus of murine RIP3. The immunogen is located within the last 50 amino acids of RIP3.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 246240, 56532
Target Species Mouse, Rat, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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