Invitrogen™ Ripertamab Recombinant Monoclonal Antibody

Catalog No.	Quantity
MA559182	1 mg
MA559181	100 μg

Catalog No. MA559182 Supplier Invitrogen™ Supplier No. MA559182

Description

Recombinant Monoclonal Antibody

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

Ripertamab, also known as SCT400, is a recombinant chimeric human-mouse anti-CD20 monoclonal antibody. The CD20 gene, also known as MS4A1, encodes a B cell-specific membrane-bound protein that plays a crucial role in B cell development and function. Located on chromosome 11q12 in humans, the MS4A1 gene spans 16 kb and includes eight exons. CD20 is a part of the membrane-spanning 4-domain family, subfamily A (MS4A), which encompasses 18 tetraspan proteins. The prominent CD20 mRNA variant is 2.8 kb long, although other shorter variants exist. This phosphoprotein, approximately 33-37 kDa, is expressed on the surface of almost all normal and malignant B cells, making it an ideal target for therapeutic antibodies like rituximab. CD20 is known to interact with several proteins such as CD40, MHCII, and CD81, playing a role in B cell receptor signaling and other immune processes. Despite its widespread clinical use in B cell depletion therapies, the precise biological function of CD20 remains partly unresolved.

Specifications

• Antigen: Ripertamab Chimeric
• Applications: ELISA, Flow Cytometry, Functional Assay, Surface Plasmon Resonance
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: 25mM Histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2
• Host Species: Human
• Purification Method: Protein A
• Quantity: 1 mg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1