RIPK1 Monoclonal Antibody (OTI2F4), TrueMAB™, OriGene

Catalog No.	Quantity
50-167-8246	100 μL

Catalog No. 50-167-8246 Supplier OriGene Supplier No. TA800311

Description

Mouse Monoclonal Antibody

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at ′Ser-728′ in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via ′Lys-63′-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

Specifications

• Antigen: RIPK1
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI2F4
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: RIPK1
• Gene Accession No.: Q13546
• Gene Alias: RIP, RIP-1, RIP1
• Gene Symbols: RIPK1
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 133-422 of human RIPK1 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8737
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1