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Tocris Bioscience™ RKI 1447 dihydrochloride Available on GSA/VA Contract for Federal Government customers only.

Potent and selective ROCK inhibitor; antitumor

Manufacturer:  Tocris Bioscience™ 5061/50

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Catalog No. 50-615-0R


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Description

Description

Potent and selective ROCK inhibitor (IC50 values are 6.2 and 14.5 nM for ROCK2 and ROCK1 respectively); suppresses phosphorylation of ROCK substrates MLC-2 and MYPT-1 in human cancer cells, but has no effect on the phosphorylation levels of Akt, MEK, and S6 kinase. Displays anti-invasive and antitumor activities in breast cancer cells.

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Specifications

Specifications

RKI 1447 dihydrochloride
>99
50mg
RKI 1447 dihydrochloride
399.29
1782109-09-4
SDS
Documents
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