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  8. RN 1747, Tocris Bioscience™

RN 1747, Tocris Bioscience™

Catalog No. 374510
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Catalog No. Quantity
37-451-0 10 mg
37-455-0 50 mg
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Catalog No. 37-451-0 Supplier R&D Systems Supplier No. 3745/10
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Description

Selective TRPV4 agonist

Selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC50 = 4 μM).

Chemical Identifiers

CAS 1024448-59-6
Molecular Formula C17H18ClN3O4S
Molecular Weight (g/mol) 395.858
InChI Key ZNLVYSJQUMALEO-UHFFFAOYSA-N
Synonym 4-chloro-2-nitro-1-4-benzylpiperazinyl sulfonyl benzene, 1-benzyl-4-4-chloro-2-nitrobenzenesulfonyl piperazine, d0a5ly, rn hplc, 1-4-chloro-2-nitrophenyl sulfonyl-4-benzylpiperazine, 1-benzyl-4-4-chloro-2-nitrophenyl sulfonylpiperazine, 1-4-chloro-2-nitrophenyl sulfonyl-4-benzylpiperazine;, 1-benzyl-4-4-chloro-2-nitrobenzene sulfonyl piperazine, 1-4-chloro-2-nitrophenyl sulfonyl-4-phenylmethyl-piperazine
PubChem CID 5068295
IUPAC Name 1-benzyl-4-(4-chloro-2-nitrophenyl)sulfonylpiperazine
SMILES C1CN(CCN1CC2=CC=CC=C2)S(=O)(=O)C3=C(C=C(C=C3)Cl)[N+](=O)[O-]

Specifications

Quantity 10 mg
Formula Weight 395.87
Percent Purity >98%
Chemical Name or Material RN 1747

Safety and Handling

Recommended Storage Store at +4°C
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