RNA pol II CTD Monoclonal Antibody, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Invitrogen 491033

Catalog No. 49-103-3

Description

This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.

RNA pol II CTD Monoclonal antibody specifically detects RNA pol II CTD in Human, Mouse, X. laevis samples. It is validated for ChIP Assay, ChIP sequencing (ChIP-seq), Immunocytochemistry, Western Blot.

Specifications

• Antigen: RNA pol II CTD
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: POLR2A
• Gene Alias: 220kDa; AW321876; DNA polymerase alpha 1 catalytic subunit; DNA polymerase alpha 1, 180 kDa; DNA polymerase alpha 1, catalytic subunit; DNA polymerase alpha catalytic subunit; DNA polymerase alpha catalytic subunit p180; DNA polymerase alpha p180 subunit; DNA polymerase alpha subunit I; DNA polymerase epsilon catalytic subunit; DNA polymerase epsilon catalytic subunit A; DNA polymerase II subunit A; DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase II subunit RPB1; DNA-directed RNA polymerase III largest subunit; DUN2; EC 2.7.7.6; G7a/Bat6Hom; hRPB220; hsRPB1; I79_002751; I79_016081; MGC75453; N0825; NSX; p180; Pol II S2p; POL2; Pola; Pola1; POLR2; POLR2A; POLRA; polymerase (DNA directed), alpha 1; polymerase (DNA directed), alpha 1, catalytic subunit; polymerase (DNA) alpha 1, catalytic subunit; polymerase (DNA-directed), alpha (70kD); Polymerase (RNA II (DNA directed), large polypeptide; polymerase (RNA) II (DNA directed) polypeptide A; polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; polymerase (RNA) II subunit A; POLYMERASE II; polymerase, alpha 1; RNA; RNA POL2; RNA polymerase II 1; RNA polymerase II largest subunit; RNA polymerase II subunit A; RNA polymerase II subunit B1; RNA-directed RNA polymerase II subunit RPB1; RP02; Rpb1; RPB220; RPBh1; Rpii215; RpIILS; RPO2; RPO21; Rpo2-1; RPOL2; SUA8; YNL262W
• Host Species: Mouse
• Purification Method: Unpurified
• Regulatory Status: RUO
• Gene ID (Entrez): 20020, 5430
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ChIP Assay, ChIP sequencing (ChIP-seq), Immunocytochemistry, Western Blot
• Concentration: Conc. Not Determined
• Formulation: ascites with <0.1% sodium azide
• Gene Accession No.: P08775, P24928
• Gene Symbols: POLR2A
• Immunogen: Raised against the largest subunit of RNA polymerase II of wheat germ and interacts with the highly conserved C-terminal domain of this protein containing the repeat YSPTSPS.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, X. laevis
• Product Type: Antibody
• Isotype: IgG2a

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov