RNF11 Monoclonal Antibody (OTI1G10), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-3785	100 μL

Catalog No. 50-168-3785 Supplier OriGene Supplier No. TA811049

Description

Mouse Monoclonal Antibody

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates ′Lys-63′ polyubiquitin chains on RIPK1 and catalyzes the formation of ′Lys-48′-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

Specifications

• Antigen: RNF11
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI1G10
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: RNF11
• Gene Accession No.: Q9Y3C5
• Gene Alias: CGI-123, SID1669
• Gene Symbols: RNF11
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 2-154 of human RNF11 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 26994
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1