Invitrogen™ Rnf11 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106994

Catalog No. PIPA5106994

Description

Sequence homology: Cow: 100%; Guinea Pig: 100%; Horse: 79%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%.

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

Specifications

• Antigen: Rnf11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RNF11
• Gene Alias: CGI-123; N4wbp2; NEDD4 WW domain-binding protein 2; RING finger protein 11; Rnf11; Sid 1669; SID1669
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26994, 689577
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q9Y3C5
• Gene Symbols: RNF11
• Immunogen: Synthetic peptide located within the following region: SDDISLLHES QSDRASFGEG TEPDQEPPPP YQEQVPVPVY HPTPSQARLA (aa 10-59).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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