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Invitrogen™ Rnf11 Polyclonal Antibody
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Catalog No. PIPA5106994
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100 μL
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Catalog No. Quantity
PIPA5106994 100 μL
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Catalog No. PIPA5106994 Supplier Invitrogen™ Supplier No. PA5106994
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Description

Rabbit Polyclonal Antibody

Sequence homology: Cow: 100%; Guinea Pig: 100%; Horse: 79%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%.

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Rnf11
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
Gene RNF11
Gene Accession No. Q9Y3C5
Gene Alias CGI-123; N4wbp2; NEDD4 WW domain-binding protein 2; RING finger protein 11; Rnf11; Sid 1669; SID1669
Gene Symbols RNF11
Host Species Rabbit
Immunogen Synthetic peptide located within the following region: SDDISLLHES QSDRASFGEG TEPDQEPPPP YQEQVPVPVY HPTPSQARLA (aa 10-59).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26994, 689577
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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