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RNF168 Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 213931AP

Catalog No. 50-173-3402


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Description

Description

RNF168 was identified as a chromatin-associated RING finger protein that acts as a ubiquitin ligase both in vitro and in vivo. RNF168 targets histones H2A and H2AX, but not H2B, forming K63 polyubiquitin chains. Upon formation of DNA double strand breaks, RNF168 is recruited to the site of DNA damage where it co-localizes with -gammaH2AX and 53BP1 in an RNF8-dependent manner. This localization of RNF168 increases the local concentration of ubiquinated proteins to the threshold required for retention of the proteins 53BP1 and BRCA1, facilitating the downstream signaling cascade. Thus, RNF168 defines a new pathway demonstrating a functional cooperation between E3 ligases in genome maintece. At least three isoforms of RNF168 are known to exist.
Specifications

Specifications

RNF168
0.49 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q8IYW5
ring finger protein 168, RNF168
Rabbit
IgG
150 μL
-20°C
Primary
165918
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Unconjugated
RNF168
Liquid
RNF168
RNF168 Fusion Protein Ag16055
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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