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Invitrogen™ RNF185 Polyclonal Antibody
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Catalog No. PIPA578615
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100 μL
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PIPA578615 100 μL
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Catalog No. PIPA578615 Supplier Invitrogen™ Supplier No. PA578615
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Description

Rabbit Polyclonal Antibody

Positive Control: human RNF185-transfected 293T Predicted Reactivity: Mouse (98%), Rat (98%), Zebrafish (83%), Xenopus laevis (91%), Chicken (87%), Bovine (98%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

RNF185 is a E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating Lys-63-linked polyubiquitination of BNIP1. RNF185 acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. RNF185 protects cells from ER stress-induced apoptosis. is responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway, and is preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RNF185
Applications Western Blot
Classification Polyclonal
Concentration 0.68 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene RNF185
Gene Accession No. Q96GF1
Gene Alias BSK65-MONO1; BSK65-MONO2; BSK65-PANC1; BSK65-PANC2; BSK65-TEST1; BSK65-TEST2; BSK65-TEST3; E3 ubiquitin-protein ligase RNF185; FLJ38628; I79_017427; ring finger protein 185; RING-type E3 ubiquitin transferase RNF185; rn185; Rnf185
Gene Symbols RNF185
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human RNF185. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 91445
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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