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Ro 106-9920, Tocris Bioscience™

Catalog No. 177850
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Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Inhibitor of NF-κB activation

Inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.

Chemical Identifiers

CAS 62645-28-7
Molecular Formula C10H7N5OS
Molecular Weight (g/mol) 245.26
InChI Key JFSXSNSCPNFCDM-UHFFFAOYSA-N
Synonym 6-benzenesulfinyl tetrazolo 1,5-b pyridazine, tetrazolo 1,5-b pyridazine, 6-phenylsulfinyl, 6-benzenesulfinyl-1,2,3,4 tetrazolo 1,5-b pyridazine, tocris-1778, tetrazolopyridazine-phenylsulfoxide, 6-phenylsulfinyl tetrazolo 1,5-b pyridazine
PubChem CID 3906779
IUPAC Name 6-(benzenesulfinyl)tetrazolo[1,5-b]pyridazine
SMILES C1=CC=C(C=C1)S(=O)C2=NN3C(=NN=N3)C=C2

Specifications

Quantity 50 mg
Formula Weight 245.26
Percent Purity >99%
Chemical Name or Material Ro 106-9920

Safety and Handling

Recommended Storage Store at +4°C
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