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Tocris Bioscience™ RO 8191

Catalog No. 737510
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10 mg
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73-751-0 10 mg
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Catalog No. 73-751-0 Supplier Tocris Bioscience™ Supplier No. 7375/10
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Description

IFNα receptor 2 agonist

RO 8191 is an IFNα receptor 2 (IFNAR2) agonist (EC50 = 0.2 μM). RO 8191 induces phosphorylation and activation of STAT1 and STAT2. RO 8191 inhibits hepatitis C (HCV) cell culture-produced infectious particles and HCV subgenomic replicon (IC50 values 0.20 μM and 0.17 μM, respectively) and inhibits hepatitis B virus replication in cell cultures (IC50 = 0.1 μM). In an animal model RO 8191 inhibits prion invasion and prolongs survival; it also reverses the inhibitory effect of integrin β6 (ITGB6) on the JAK/STAT3 signaling and the epithelial-to-mesenchymal transition pathway and inhibits the proliferation, invasion, and migration of cervical cancer cells. Orally bioavailable.

Specifications

Chemical Name or Material 8-(1,3,4-Oxadiazol-2-yl)-2,4-bis(trifluoromethyl)imidazo[1,2-a][1,8 ]naphthyridine
CAS 691868-88-9
Quantity 10 mg
Target IFN-alpha/beta R2
Molecular Formula C14H5F6N5O
Purity 0.98
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