Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
ROCK1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody
Supplier: Proteintech Group Inc 218501AP150UL

Description
The Rho target protein, Rho-associated coiled coil-containing protein kinase (ROCK)-1 has been found to be a new Caspase-3 substrate. ROCK, one of the effectors of the small GTPase Rho, has recently been shown to contribute significantly to myosin light chain (MLC) activation through two pathways: direct phosphorylation of MLC and phosphorylation of MLC phosphatase, leading to its inhibition. The increase in cellular contractility that is necessary for apoptotic membrane blebbing implies sustained augmentation of MLC phosphorylation. ROCK-1 consists of an amino-terminal kinase domain and an inhibitory cysteine/histidine-rich C-terminal domain that is located within a pleckstrin-homology region. They are joined by a variable region that contains the Rho-binding domain. During apoptosis, ROCK-I is cleaved by caspase-3 at a conserved DETD1113/G sequence and its carboxy-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity. The caspase-3-mediated cleavage and activation of ROCK I induces phosphorylation of MLC and membrane blebbing, one of the first events in the execution phase of apoptosis.Specifications
ROCK1 | |
Polyclonal | |
Unconjugated | |
ROCK1 | |
p160 ROCK 1, P160ROCK, PRO0435, ROCK1 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
19877, 6093, 81762 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
0.35 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P70335, Q13464, Q63644 | |
ROCK1 | |
ROCK1 Fusion Protein Ag16317 | |
150 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Product Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction