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ROR gamma (t) Monoclonal Antibody (AFKJS-9), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

$196.00 - $462.00

Specifications

Antigen ROR gamma (t)
Clone AFKJS-9
Concentration 0.5 mg/mL
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-135-64
Encompass_Preferred
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Invitrogen™
14698880
25 μg
Each for $196.00
Only null left
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50-135-65
Encompass_Preferred
View Documents
Invitrogen™
14698882
100 μg
Each for $462.00
Only null left
Edge
Add to Cart
 
Description

Description

Description: The AFKJS-9 monoclonal antibody reacts with the mouse, human and rhesus monkey ROR gamma (t) protein. ROR gamma is a member of the retinoic acid-related orphan receptor (ROR) family, which also includes ROR alpha and ROR beta. ROR family proteins are ligand-dependent transcription factors that play roles in multiple physiological processes. ROR gamma is expressed in several tissues including liver, lung, muscle, heart and kidney. Furthermore, it was discovered that alternative transcription results in the expression of an isoform, ROR gamma (t), which is expressed exclusively in cells of the lymphoid compartment, namely CD4+CD8+ double-positive thymocytes, Th17 cells of the periphery and lymphoid tissue inducer (LTi) cells of lymphoid organs. The ROR gamma (t) isoform differs from ROR gamma by three unique amino acids at its amino terminus. Therefore, the AFKJS-9 antibody will react with both the ROR gamma and ROR gamma (t) isoforms. Applications Reported: This AFKJS-9 antibody has been reported for use in chromatin immunoprecipitation and western blotting. Applications Tested: This AFKJS-9 antibody has been tested by western blot analysis. This can be used at less than or equal to 5 μg per mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.

ROR gamma, a NR1 Thyroid Hormone-Like receptor, has been shown to affect thymopoiesis, bone metabolism, T-cell apoptosis, and lymphoid organogenesis. ROR gamma has been shown to promote thymocyte survival by activating the expression of the antiapoptotic protein Bcl-x(L). ROR gamma is also required for the development of lymph nodes and Peyer's patches. It has been shown that ROR gamma(t), a thymus-specific isoform of ROR gamma from mouse, inhibits Fas ligand expression and cytokine secretion in immature thymocytes. ROR gamma binds as a monomer to response elements composed of a single core motif, GGTCA, preceded by a 6 bp AT-rich sequence. ROR gamma expression has been documented in mouse thymus, adipose, bone, skeletal muscle, liver, and kidney, and in human skeletal muscle. ESTs have been isolated from human tissue libraries, including cancerous head/neck, germ cell, and prostate, and normal colon, head/neck, lung, liver/spleen, and pancreas. ROR gammat t (RORgt) is an isoform of RORC.
Specifications

Specifications

ROR gamma (t)
0.5 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
EGK_01272; IMD42; MGC129539; NR1F3; nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; nuclear receptor subfamily 1 group F member 3; RAR related orphan receptor C; RAR-related orphan nuclear receptor variant 2; RAR-related orphan receptor C; RAR-related orphan receptor C, isoform a; RAR-related orphan receptor gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; retinoid-related orphan receptor-gamma; ROR Gamma; ROR gamma t; Rorc; Rorg; RORgamma; RORgt; RP11-98D18.11-001; RZRG; RZR-GAMMA; Thor; Thymus orphan receptor; TOR
Rorc
Primary
4°C
Rorc
AFKJS-9
Immunoprecipitation, Western Blot
Unconjugated
Rat
Human, Mouse, Rhesus Macaque
P51449, P51450
19885, 6097, 717052
IgG2a κ
Affinity Chromatography
Antibody
Videos
SDS
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Documents

Product Certifications

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