Invitrogen™ RPE65 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578414

Catalog No. PIPA578414

Description

Positive Control: mouse eye Predicted Reactivity: Rat (93%), Xenopus laevis (83%), Dog (97%), Chicken (89%), Bovine (98%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

RPE65 is a major protein of the retinal pigment epithelium (RPE). RPE65 is essential for the regeneration of rhodopsin in the visual cycle. Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA). Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE.

Specifications

• Antigen: RPE65
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RPE65
• Gene Alias: 65kDa; A930029L06Rik; all-trans-retinyl-palmitate hydrolase; BCO family, member 3; BCO3; LCA2; Lutein isomerase; membrane receptor p63; meso-zeaxanthin isomerase; modifier of retinal degeneration 1; Mord1; mRPE65; p63; RBP-binding membrane protein; rd12; retinal pigment epithelium 65; retinal pigment epithelium 65-like; retinal pigment epithelium abundant protein RPE65; retinal pigment epithelium specific protein 65; retinal pigment epithelium, 65 kDa; retinal pigment epithelium-specific 65 kDa protein; retinal pigment epithelium-specific 65kD protein; retinal pigment epithelium-specific protein (65kD); retinal pigment epithelium-specific protein 65kDa; retinal pigment epithelium-specific protein RPE65; Retinitis pigmentos; retinitis pigmentosa 20 (autosomal recessive); retinoid isomerohydrolase; retinoid isomerohydrolase RPE65; retinol isomerase; RP20; RPE65; rpe65 gene for retinal pigment epithelium-specific protein; RPE65, retinoid isomerohydrolase; sRPE65; truncated RPE65
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19892, 6121
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.36 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q16518, Q91ZQ5
• Gene Symbols: RPE65
• Immunogen: Recombinant protein encompassing a sequence within the center region of human RPE65. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG